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The unique physical and chemical properties of gold nanoparticles (AuNPs) make them suitable vehicles to pursuit this goal. In recent years, nanotechnology has paved the way for the development of a plethora of new diagnostic and therapeutic platforms, fostering theranostics. The knowledge of the role of exosomes in tumorigenesis prompted a new era in cancer diagnostics and therapy, taking advantage of the use of circulating exosomes as tumor biomarkers due to their stability in body fluids and targeting malignant exosomes’ release and/or uptake to inhibit or delay tumor development. Exosomes secreted by cancer cells, malicious exosomes, have important roles in tumor microenvironment maturation and cancer progression.

Fernandes, Alexandra R.Įxosomes are nanovesicles formed in the endosomal pathway with an important role in paracrine and autocrine cell communication. Cabral, Rita Paradinha, Fabiana Baptista, Pedro V. Roma-Rodrigues, Catarina Raposo, Luís R. Tumor Microenvironment Modulation via Gold Nanoparticles Targeting Malicious Exosomes: Implications for Cancer Diagnostics and Therapy Overall, we conclude that examining malicious activity at AS granularity can unearth networks with lax security or those that harbor cybercrime.« less We also find that malicious ASes as a whole differ from benign ones in other properties not obviously related to their malicious activities, such as more frequent connectivity changes with their BGP peers. Several ASes regularlymore » peer with ASes associated with significant malicious activity. Yet others account for large fractions of blacklisted IP addresses. We find that some ASes have over 80% of their routable IP address space blacklisted.

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We look for ISPs and ASes that exhibit disproportionately high malicious behavior using ten popular blacklists, plus local spam data, and extensive DNS resolutions based on the contents of the blacklists.

In this paper, we explore whether some ASes indeed are safe havens for malicious activity. While many attacks are distributed across botnets, investigators and network operators have recently targeted malicious networks through high profile autonomous system (AS) de-peerings and network shut-downs. The…Ībnormally Malicious Autonomous Systems and their Internet Connectivity This research analyzed Facebook users' level of understanding in the domain of malicious social engineering on Facebook.

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Users of Facebook therefore should be aware of various malicious attacks and know how to identify them.

With the rapid growth of Facebook, the social networking website is becoming a lucrative target for malicious activity. Overall, we conclude that examining malicious activity at the AS granularity can unearth networks with lax security or thosemore » that harbor cybercrime.« lessĪwareness of Malicious Social Engineering among Facebook Users We find that some ASes have over 80% of their routable IP address space blacklisted and others account for large fractions of blacklisted IPs. We look for ISPs and ASes that exhibit disproportionately high malicious behavior using 12 popular blacklists.

Malicious Hubs: Detecting Abnormally Malicious Autonomous Systems Beyond nuisance spam or phishing designed to trick users into revealing personal information, targeted malicious email (TME) facilitates computer network exploitation and the gathering of sensitive… Targeted email attacks to enable computer network exploitation have become more prevalent, more insidious, and more widely documented in recent years. Detecting Targeted Malicious Email through Supervised Classification of Persistent Threat and Recipient Oriented FeaturesĮRIC Educational Resources Information Center